Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke

…, K Arimura, T Ago, M Tachibana, A Nishimura… - Experimental …, 2015 - Elsevier
Fibrosis is concomitant with repair processes following injuries in the central nervous system
(CNS). Pericytes are considered as an origin of fibrosis-forming cells in the CNS. Here, we …

Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin

R Kurogi, K Nishimura, M Nakai, A Kada, S Kamitani… - Neurology, 2018 - AAN Enterprises
Objectives This cross-sectional survey explored the characteristics and outcomes of direct
oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by …

Detrimental role of pericyte Nox4 in the acute phase of brain ischemia

A Nishimura, T Ago, J Kuroda… - Journal of Cerebral …, 2016 - journals.sagepub.com
Pericytes are mural cells abundantly present in cerebral microvessels and play important
roles, including the formation and maintenance of the blood–brain barrier. Nox4 is a major …

Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke

K Nakamura, K Arimura, A Nishimura, M Tachibana… - brain research, 2016 - Elsevier
Central nervous system (CNS) pericytes have been recognized as an indispensable component
of the neurovascular unit. The expression of platelet-derived growth factor receptor β (…

Nox4 is a major source of superoxide production in human brain pericytes

J Kuroda, T Ago, A Nishimura, K Nakamura… - Journal of vascular …, 2015 - karger.com
Background: Pericytes are multifunctional cells surrounding capillaries and postcapillary
venules. In brain microvasculature, pericytes play a pivotal role under physiological and …

Early reperfusion after brain ischemia has beneficial effects beyond rescuing neurons

…, M Shijo, Y Yoshikawa, M Komori, A Nishimura… - Stroke, 2017 - Am Heart Assoc
Background and Purpose— Recent studies show that successful endovascular thrombectomy
6 to 12 hours after stroke onset enhances functional outcomes 3 months later. In this study…

Status and future perspectives of utilizing big data in neurosurgical and stroke research

A Nishimura, K Nishimura, A Kada, K Iihara… - Neurologia medico …, 2016 - jstage.jst.go.jp
The management, analysis, and integration of Big Data have received increasing attention
in healthcare research as well as in medical bioinformatics. The J-ASPECT study is the first …

[HTML][HTML] Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and …

…, A Kurogi, K Nishimura, K Arimura, A Nishimura… - PloS one, 2020 - journals.plos.org
Objective We sought to examine whether the effect of treatment modality and drugs for cerebral
vasospasm on clinical outcomes differs between elderly and non-elderly subarachnoid …

4D ASL-based MR angiography for visualization of distal arteries and leptomeningeal collateral vessels in moyamoya disease: a comparison of techniques

…, M Obara, K Yamashita, D Momosaka, A Nishimura… - European …, 2018 - Springer
Objectives To evaluate the performance of four-dimensional pseudo-continuous arterial
spin labeling (4D-pCASL)-based angiography using CENTRA-keyhole and view sharing (4D-…

Vessel-selective 4D-MR angiography using super-selective pseudo-continuous arterial spin labeling may be a useful tool for assessing brain AVM hemodynamics

…, K Kikuchi, D Momosaka, Y Kikuchi, A Nishimura… - European …, 2020 - Springer
Objectives To evaluate the usefulness of 4D-MR angiography based on super-selective
pseudo-continuous ASL combined with keyhole and view-sharing (4D-S-PACK) for vessel-…