User profiles for Ashley L. Kalinski

Ashley Kalinski

Ball State University
Verified email at bsu.edu
Cited by 905

A new neutrophil subset promotes CNS neuron survival and axon regeneration

…, AD Jerome, R Menon, C Yoon, AL Kalinski… - Nature …, 2020 - nature.com
Transected axons typically fail to regenerate in the central nervous system (CNS), resulting
in chronic neurological disability in individuals with traumatic brain or spinal cord injury, …

Locally translated mTOR controls axonal local translation in nerve injury

…, JA Oses-Prieto, C Forester, C Gomes, AL Kalinski… - Science, 2018 - science.org
How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic
target of rapamycin) was activated and then up-regulated in injured axons, owing to local …

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C high monocytes …

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

AL Kalinski, AN Kar, J Craver, AP Tosolini… - Journal of Cell …, 2019 - rupress.org
Inhibition of histone deacetylase 6 (HDAC6) was shown to support axon growth on the
nonpermissive substrates myelin-associated glycoprotein (MAG) and chondroitin sulfate …

A HuD‐ZBP1 ribonucleoprotein complex localizes GAP‐43 mRNA into axons through its 3′ untranslated region AU‐rich regulatory element

…, P Kim, CJ Donnelly, AL Kalinski… - Journal of …, 2013 - Wiley Online Library
Localized translation of axonal mRNA s contributes to developmental and regenerative axon
growth. Although untranslated regions (UTRs) of many different axonal mRNA s appear to …

The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

…, H Hafner, M Athaiya, MC Finneran, AL Kalinski… - Elife, 2022 - elifesciences.org
Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable
degree of spontaneous anatomical and functional regeneration. To explore extrinsic …

[PDF][PDF] Nucleolin-mediated RNA localization regulates neuron growth and cycling cell size

RBT Perry, I Rishal, E Doron-Mandel, AL Kalinski… - Cell reports, 2016 - cell.com
How can cells sense their own size to coordinate biosynthesis and metabolism with their
growth needs? We recently proposed a motor-dependent bidirectional transport mechanism for …

mRNAs and protein synthetic machinery localize into regenerating spinal cord axons when they are provided a substrate that supports growth

AL Kalinski, R Sachdeva, C Gomes, SJ Lee… - Journal of …, 2015 - Soc Neuroscience
Although intra-axonal protein synthesis is well recognized in cultured neurons and during
development in vivo, there have been few reports of mRNA localization and/or intra-axonal …

Neuroinflammation: Breaking barriers and bridging gaps

…, JA Headen, RE Williamson, AL Kalinski - Neuroscience …, 2021 - Elsevier
Neurons are the cells of the nervous system and are responsible for every thought, movement
and perception. Immune cells are the cells of the immune system, constantly protecting …

[HTML][HTML] Intra-axonal protein synthesis–a new target for neural repair?

JL Twiss, AL Kalinski, R Sachdeva… - Neural Regeneration …, 2016 - journals.lww.com
Although initially argued to be a feature of immature neurons with incomplete polarization,
there is clear evidence that neurons in the peripheral nervous system retain the capacity for …