[HTML][HTML] Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure

…, JA Short, H Sosa, GM Perez, AE Tschiffely… - Molecular …, 2021 - nature.com
Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative
diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (…

[HTML][HTML] Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain

…, A Spencer, PL Janssen, AE Tschiffely… - Acta neuropathologica …, 2019 - Springer
Much concern exists over the role of blast-induced traumatic brain injury (TBI) in the chronic
cognitive and mental health problems that develop in veterans and active duty military …

PTSD-related behavioral traits in a rat model of blast-induced mTBI are reversed by the mGluR2/3 receptor antagonist BCI-838

…, MAG Sosa, GM Perez, A Otero-Pagan, A Tschiffely… - Eneuro, 2018 - eneuro.org
Battlefield blast exposure related to improvised explosive devices (IEDs) has become the
most common cause of traumatic brain injury (TBI) in the recent conflicts in Iraq and …

[HTML][HTML] Blast-related mild TBI alters anxiety-like behavior and transcriptional signatures in the rat amygdala

…, M Umali, N Mendelev, AE Tschiffely… - Frontiers in behavioral …, 2020 - frontiersin.org
The short and long-term neurological and psychological consequences of traumatic brain
injury (TBI), and especially mild TBI (mTBI) are of immense interest to the Veteran community. …

Blast-induced" PTSD": Evidence from an animal model

…, MAG Sosa, R De Gasperi, AE Tschiffely… - …, 2019 - Elsevier
A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan
has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-…

Assessing a blast-related biomarker in an operational community: glial fibrillary acidic protein in experienced breachers

AE Tschiffely, JK Statz, KA Edwards… - Journal of …, 2020 - liebertpub.com
Mild traumatic brain injury (mTBI) is a risk for military personnel due to blast overpressures,
which may result from a variety of sources, including artillery and improvised explosive …

Exposure to Low-Intensity Blast Increases Clearance of Brain Amyloid Beta

…, C Watson, U Kawoos, JK Statz, AE Tschiffely… - Journal of …, 2024 - liebertpub.com
The long-term effects of exposure to blast overpressure are an important health concern in
military personnel. Increase in amyloid beta (Aβ) has been documented after non-blast …

Repetitive low-level blast exposure improves behavioral deficits and chronically lowers Aβ42 in an Alzheimer disease transgenic mouse model

G Perez Garcia, R De Gasperi, AE Tschiffely… - Journal of …, 2021 - liebertpub.com
Public awareness of traumatic brain injury (TBI) in the military increased recently because of
the conflicts in Iraq and Afghanistan where blast injury was the most common mechanism of …

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

AE Tschiffely, RA Schuh, K Prokai-Tatrai, L Prokai… - Hormones and …, 2016 - Elsevier
Estrogens are neuroprotective and, thus, potentially useful for the therapy of Alzheimer's
disease; however, clinical use of hormone therapy remains controversial due to adverse …

Unsupervised network discovery for brain imaging data

Z Bai, P Walker, A Tschiffely, F Wang… - Proceedings of the 23rd …, 2017 - dl.acm.org
A common problem with spatiotemporal data is how to simplify the data to discover an
underlying network that consists of cohesive spatial regions (nodes) and relationships between …