User profiles for Andrew J. Trevelyan

Andrew Trevelyan

Newcastle University
Verified email at ncl.ac.uk
Cited by 3912

[HTML][HTML] Evidence of an inhibitory restraint of seizure activity in humans

…, R Yuste, RG Emerson, AJ Trevelyan - Nature …, 2012 - nature.com
The location and trajectory of seizure activity is of great importance, yet our ability to map
such activity remains primitive. Recently, the development of multi-electrode arrays for use in …

Modular propagation of epileptiform activity: evidence for an inhibitory veto in neocortex

AJ Trevelyan, D Sussillo, BO Watson… - Journal of …, 2006 - Soc Neuroscience
What regulates the spread of activity through cortical circuits? We present here data
indicating a pivotal role for a vetoing inhibition restraining modules of pyramidal neurons. We …

Feedforward inhibition contributes to the control of epileptiform propagation speed

AJ Trevelyan, D Sussillo, R Yuste - Journal of Neuroscience, 2007 - Soc Neuroscience
It is still poorly understood how epileptiform events can recruit cortical circuits. Moreover, the
speed of propagation of epileptiform discharges in vivo and in vitro can vary over several …

Ictal high frequency oscillations distinguish two types of seizure territories in humans

…, RR Goodman, RG Emerson, AJ Trevelyan… - Brain, 2013 - academic.oup.com
High frequency oscillations have been proposed as a clinically useful biomarker of seizure
generating sites. We used a unique set of human microelectrode array recordings (four …

[HTML][HTML] The contribution of raised intraneuronal chloride to epileptic network activity

…, K Deisseroth, C Racca, AJ Trevelyan - Journal of …, 2015 - Soc Neuroscience
Altered inhibitory function is an important facet of epileptic pathology. A key concept is that
GABAergic activity can become excitatory if intraneuronal chloride rises. However, it has …

[HTML][HTML] The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

…, RG Emerson, LM Bateman, AJ Trevelyan… - Nature …, 2016 - nature.com
The extensive distribution and simultaneous termination of seizures across cortical areas
has led to the hypothesis that seizures are caused by large-scale coordinated networks …

How inhibition influences seizure propagation

AJ Trevelyan, CA Schevon - Neuropharmacology, 2013 - Elsevier
Inhibitory neuron behaviour is of fundamental importance to epileptic pathophysiology. When
inhibition is compromised, such as by GABAergic blockade (Curtis et al., 1970; Connors, …

Neural stem cells in the adult subventricular zone oxidize fatty acids to produce energy and support neurogenic activity

EA Stoll, R Makin, IR Sweet, AJ Trevelyan, S Miwa… - Stem …, 2015 - academic.oup.com
Neural activity is tightly coupled to energy consumption, particularly sugars such as glucose.
However, we find that, unlike mature neurons and astrocytes, neural stem/progenitor cells (…

Seizure localization using ictal phase-locked high gamma: A retrospective surgical outcome study

…, B Diehl, AW McEvoy, MC Walker, AJ Trevelyan… - Neurology, 2015 - AAN Enterprises
Objective: To determine whether resection of areas with evidence of intense, synchronized
neural firing during seizures is an accurate indicator of postoperative outcome. Methods: …

Single unit action potentials in humans and the effect of seizure activity

…, RG Emerson, CA Schevon, AJ Trevelyan - Brain, 2015 - academic.oup.com
See Kimchi and Cash (doi: 10.1093/awv264 ) for a scientific commentary on this article.
Spike-sorting algorithms have been used to identify the firing patterns of isolated neurons (‘…