Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

N Rebola, AP Simões, PM Canas… - Journal of …, 2011 - Wiley Online Library
J. Neurochem. (2011) 117, 100–111. Abstract The blockade of adenosine A 2A receptors (A2AR)
affords a robust neuroprotection in different noxious brain conditions. However, the …

Activity and expression of a virulence factor, gelatinase, in dairy enterococci

MFS Lopes, AP Simões, R Tenreiro… - International journal of …, 2006 - Elsevier
In order to understand the virulence potential of dairy enterococci, 35 isolates from raw ewe's
milk and traditionally fermented cheeses, identified as Enterococcus faecalis, Enterococcus …

[HTML][HTML] Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory

AP Simões, NJ Machado, N Gonçalves… - …, 2016 - nature.com
The consumption of caffeine modulates working and reference memory through the
antagonism of adenosine A 2A receptors (A 2A Rs) controlling synaptic plasticity processes in …

[PDF][PDF] Equidade horizontal no acesso a consultas de clínica geral, cardiologia e medicina dentária em Portugal

AP Simões, AT Paquete, M Araújo - Revista Portuguesa de Saúde …, 2008 - run.unl.pt
A relevância da equidade no sector da saúde motivou a elaboração do presente trabalho. A
noção de equidade aqui utilizada foi a de equidade horizontal. Esta remete para uma igual …

Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease

PM Canas, AP Simões, RJ Rodrigues, RA Cunha - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is characterized phenotypically by memory impairment, neurochemically
by accumulation of β-amyloid peptide (such as Aβ 1–42 ) and morphologically by an …

Purinergic signaling orchestrating neuron-glia communication

P Agostinho, D Madeira, L Dias, AP Simões… - Pharmacological …, 2020 - Elsevier
This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) in …

Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions

PM Canas, LO Porciúncula, AP Simões, E Augusto… - Eneuro, 2018 - eneuro.org
Neurodegeneration is a process transversal to neuropsychiatric diseases and the understanding
of its mechanisms should allow devising strategies to prevent this irreversible step in …

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate …

NJ Machado, AP Simões, HB Silva, AP Ardais… - Molecular …, 2017 - Springer
Caffeine prophylactically prevents mood and memory impairments through adenosine A 2A
receptor (A 2A R) antagonism. A 2A R antagonists also therapeutically revert mood and …

Key Modulatory Role of Presynaptic Adenosine A2A Receptors in Cortical Neurotransmission to the Striatal Direct Pathway

…, R Luján, M Uchigashima, AP Simoes… - The Scientific World …, 2009 - hindawi.com
Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D 1 and D 2 receptors, respectively. …

[HTML][HTML] Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase …

AP Simões, JA Duarte, F Agasse, PM Canas… - Journal of …, 2012 - Springer
Background and purpose Blockade of adenosine A 2A receptors (A 2A R) affords robust
neuroprotection in a number of brain conditions, although the mechanisms are still unknown. A …