[HTML][HTML] A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1

NT Hertz, A Berthet, ML Sos, KS Thorn, AL Burlingame… - Cell, 2013 - cell.com
Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD).
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …

Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons

A Berthet, EB Margolis, J Zhang, I Hsieh… - Journal of …, 2014 - Soc Neuroscience
Disruptions in mitochondrial dynamics may contribute to the selective degeneration of
dopamine (DA) neurons in Parkinson's disease (PD). However, little is known about the normal …

Lentiviral Overexpression of GRK6 Alleviates l-Dopa–Induced Dyskinesia in Experimental Parkinson's Disease

MR Ahmed, A Berthet, E Bychkov, G Porras… - Science translational …, 2010 - science.org
Parkinson’s disease is caused primarily by degeneration of brain dopaminergic neurons in
the substantia nigra and the consequent deficit of dopamine in the striatum. Dopamine …

Energy failure: does it contribute to neurodegeneration?

D Pathak, A Berthet, K Nakamura - Annals of neurology, 2013 - Wiley Online Library
Energy failure from mitochondrial dysfunction is proposed to be a central mechanism leading
to neuronal death in a range of neurodegenerative diseases. However, energy failure has …

Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia

A Berthet, G Porras, E Doudnikoff, H Stark… - Journal of …, 2009 - Soc Neuroscience
We have associated behavioral, pharmacological, and quantitative immunohistochemical
study in a rat analog of l-DOPA-induced dyskinesia to understand whether alterations in …

[HTML][HTML] PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

G Porras, A Berthet, B Dehay, Q Li… - The Journal of …, 2012 - Am Soc Clin Investig
l-DOPA–induced dyskinesia (LID), a detrimental consequence of dopamine replacement
therapy for Parkinson’s disease, is associated with an alteration in dopamine D1 receptor (D1R…

Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3, 4-dihydroxyphenylalanine-induced dyskinesia

S Schuster, E Doudnikoff, D Rylander, A Berthet… - Biological …, 2009 - Elsevier
BACKGROUND: Chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment of Parkinson's
disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced …

[HTML][HTML] Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

J Tao, A Berthet, YR Citron, PL Tsiolaki… - Journal of Biological …, 2021 - ASBMB
Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology
of Parkinson's disease and related synucleinopathies. Elevated levels of the stress-…

Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation

H Li, Z Doric, A Berthet, DM Jorgens, MK Nguyen… - Science …, 2021 - science.org
Altered mitochondrial quality control and dynamics may contribute to neurodegenerative
diseases, including Parkinson’s disease, but we understand little about these processes in …

Double-dissociation of the catecholaminergic modulation of synaptic transmission in the oval bed nucleus of the stria terminalis

…, R Sharma, X Mason, A Berthet… - Journal of …, 2011 - journals.physiology.org
The bed nucleus of the stria terminalis (BST) is a cluster of nuclei within the extended
amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. …