[HTML][HTML] A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD).
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons
A Berthet, EB Margolis, J Zhang, I Hsieh… - Journal of …, 2014 - Soc Neuroscience
Disruptions in mitochondrial dynamics may contribute to the selective degeneration of
dopamine (DA) neurons in Parkinson's disease (PD). However, little is known about the normal …
dopamine (DA) neurons in Parkinson's disease (PD). However, little is known about the normal …
Lentiviral Overexpression of GRK6 Alleviates l-Dopa–Induced Dyskinesia in Experimental Parkinson's Disease
MR Ahmed, A Berthet, E Bychkov, G Porras… - Science translational …, 2010 - science.org
Parkinson’s disease is caused primarily by degeneration of brain dopaminergic neurons in
the substantia nigra and the consequent deficit of dopamine in the striatum. Dopamine …
the substantia nigra and the consequent deficit of dopamine in the striatum. Dopamine …
Energy failure: does it contribute to neurodegeneration?
D Pathak, A Berthet, K Nakamura - Annals of neurology, 2013 - Wiley Online Library
Energy failure from mitochondrial dysfunction is proposed to be a central mechanism leading
to neuronal death in a range of neurodegenerative diseases. However, energy failure has …
to neuronal death in a range of neurodegenerative diseases. However, energy failure has …
Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia
A Berthet, G Porras, E Doudnikoff, H Stark… - Journal of …, 2009 - Soc Neuroscience
We have associated behavioral, pharmacological, and quantitative immunohistochemical
study in a rat analog of l-DOPA-induced dyskinesia to understand whether alterations in …
study in a rat analog of l-DOPA-induced dyskinesia to understand whether alterations in …
[HTML][HTML] PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking
G Porras, A Berthet, B Dehay, Q Li… - The Journal of …, 2012 - Am Soc Clin Investig
l-DOPA–induced dyskinesia (LID), a detrimental consequence of dopamine replacement
therapy for Parkinson’s disease, is associated with an alteration in dopamine D1 receptor (D1R…
therapy for Parkinson’s disease, is associated with an alteration in dopamine D1 receptor (D1R…
Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3, 4-dihydroxyphenylalanine-induced dyskinesia
S Schuster, E Doudnikoff, D Rylander, A Berthet… - Biological …, 2009 - Elsevier
BACKGROUND: Chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment of Parkinson's
disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced …
disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced …
[HTML][HTML] Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism
J Tao, A Berthet, YR Citron, PL Tsiolaki… - Journal of Biological …, 2021 - ASBMB
Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology
of Parkinson's disease and related synucleinopathies. Elevated levels of the stress-…
of Parkinson's disease and related synucleinopathies. Elevated levels of the stress-…
Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation
Altered mitochondrial quality control and dynamics may contribute to neurodegenerative
diseases, including Parkinson’s disease, but we understand little about these processes in …
diseases, including Parkinson’s disease, but we understand little about these processes in …
Double-dissociation of the catecholaminergic modulation of synaptic transmission in the oval bed nucleus of the stria terminalis
…, R Sharma, X Mason, A Berthet… - Journal of …, 2011 - journals.physiology.org
The bed nucleus of the stria terminalis (BST) is a cluster of nuclei within the extended
amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. …
amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. …