User profiles for Alvaro Gomariz

Alvaro Gomariz

Data Scientist, Roche
Verified email at roche.com
Cited by 701

[PDF][PDF] Mesenchymal niche-specific expression of Cxcl12 controls quiescence of treatment-resistant leukemia stem cells

…, S Isringhausen, H Li, AJ Paterson, J He, Á Gomariz… - Cell Stem Cell, 2019 - cell.com
Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed
by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated …

[PDF][PDF] Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness

…, M Lopes, A Hausmann, WD Hardt, A Gomariz… - Cell stem cell, 2017 - cell.com
Bacterial infection leads to consumption of short-lived innate immune effector cells, which
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …

[HTML][HTML] Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy

A Gomariz, PM Helbling, S Isringhausen… - Nature …, 2018 - nature.com
Sinusoidal endothelial cells and mesenchymal CXCL12-abundant reticular cells are principal
bone marrow stromal components, which critically modulate haematopoiesis at various …

[HTML][HTML] Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

…, K Mineura, R Shibuya, A Gomariz… - Nature …, 2023 - nature.com
Transplantation of solid organs can be life-saving in patients with end-stage organ failure,
however, graft rejection remains a major challenge. In this study, by pre-conditioning with …

Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness

…, NJ Kräutler, U Suessbier, A Gomariz… - Journal of Experimental …, 2021 - rupress.org
Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM)
failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral …

Siamese networks with location prior for landmark tracking in liver ultrasound sequences

A Gomariz, W Li, E Ozkan, C Tanner… - 2019 IEEE 16th …, 2019 - ieeexplore.ieee.org
Image-guided radiation therapy can benefit from accurate motion tracking by ultrasound
imaging, in order to minimize treatment margins and radiate moving anatomical targets, eg, due …

Unsupervised domain adaptation with contrastive learning for OCT segmentation

A Gomariz, H Lu, YY Li, T Albrecht, A Maunz… - … Conference on Medical …, 2022 - Springer
Accurate segmentation of retinal fluids in 3D Optical Coherence Tomography images is key
for diagnosis and personalized treatment of eye diseases. While deep learning has been …

Imaging and spatial analysis of hematopoietic stem cell niches

A Gomariz, S Isringhausen, PM Helbling… - Annals of the New …, 2020 - Wiley Online Library
Hematopoietic stem cells (HSCs) have been long proposed to reside in defined anatomical
locations within bone marrow (BM) tissues in direct contact or close proximity to nurturing cell …

Multiparametric imaging reveals that mitochondria‐rich intercalated cells in the kidney collecting duct have a very high glycolytic capacity

S Ghazi, S Bourgeois, A Gomariz… - The FASEB …, 2020 - Wiley Online Library
Alpha intercalated cells (αICs) in the kidney collecting duct (CD) belong to a family of
mitochondria rich cells (MRCs) and have a crucial role in acidifying the urine via apical V‐ATPase …

Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness

…, M Lopes, A Hausmann, WD Hardt, Á Gomariz… - Cell Stem Cell, 2020 - cell.com
(Cell Stem Cell 21, 225–240. e1–e5; August 3, 2017) In the originally published version of
our manuscript, the database repository for the sequencing data was indicated incorrectly as …