User profiles for Alexandra V. Ulyanova

Alexandra V. Ulyanova

Assistant Professor of Neurosurgery, University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 500

Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue

…, JM Spaethling, JA Wolf, MS Grady, AV Ulyanova… - Nature …, 2014 - nature.com
Transcriptome profiling of single cells resident in their natural microenvironment depends
upon RNA capture methods that are both noninvasive and spatially precise. We engineered a …

[PDF][PDF] Primary cell culture of live neurosurgically resected aged adult human brain cells and single cell transcriptomics

JM Spaethling, YJ Na, J Lee, AV Ulyanova, GH Baltuch… - Cell reports, 2017 - cell.com
Investigation of human CNS disease and drug effects has been hampered by the lack of a
system that enables single-cell analysis of live adult patient brain cells. We developed a …

[PDF][PDF] Pervasive within-mitochondrion single-nucleotide variant heteroplasmy as revealed by single-mitochondrion sequencing

J Morris, YJ Na, H Zhu, JH Lee, H Giang, AV Ulyanova… - Cell reports, 2017 - cell.com
A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation
in multiple mitochondria. Here, we present a method for identification of variants present at …

[HTML][HTML] Multichannel silicon probes for awake hippocampal recordings in large animals

AV Ulyanova, C Cottone, CD Adam… - Frontiers in …, 2019 - frontiersin.org
Decoding laminar information across deep brain structures and cortical regions is necessary
in order to understand the neuronal ensembles that represent cognition and memory. Large …

[HTML][HTML] CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential

…, JG Rosario, SA Anderson, AV Ulyanova… - Nature …, 2023 - nature.com
Genomic DNA (gDNA) undergoes structural interconversion between single- and double-stranded
states during transcription, DNA repair and replication, which is critical for cellular …

Electrophysiological signature reveals laminar structure of the porcine hippocampus

AV Ulyanova, PF Koch, C Cottone, MR Grovola… - Eneuro, 2018 - eneuro.org
The hippocampus is integral to working and episodic memory and is a central region of
interest in diseases affecting these processes. Pig models are widely used in translational …

Traumatic brain injury preserves firing rates but disrupts laminar oscillatory coupling and neuronal entrainment in hippocampal CA1

PF Koch, C Cottone, CD Adam, AV Ulyanova… - eneuro, 2020 - eneuro.org
While hippocampal-dependent learning and memory are particularly vulnerable to traumatic
brain injury (TBI), the functional status of individual hippocampal neurons and their …

[HTML][HTML] Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles

AV Ulyanova, RE Shirokov - PLoS One, 2018 - journals.plos.org
Voltage-dependent inward currents responsible for the depolarizing phase of action
potentials were characterized in smooth muscle cells of 4 th order arterioles in mouse skeletal …

Single cell phototransfection of mRNAs encoding SARS-CoV2 spike and nucleocapsid into human astrocytes results in RNA dependent translation interference

…, MS Grady, HI Chen, JA Wolf, AV Ulyanova… - Frontiers in Drug …, 2024 - frontiersin.org
Multi-RNA co-transfection is starting to be employed to stimulate immune responses to
SARS-CoV-2 viral infection. While there are good reasons to utilize such an approach, there is …

[HTML][HTML] Hippocampal interneuronal dysfunction and hyperexcitability in a porcine model of concussion

AV Ulyanova, CD Adam, C Cottone… - Communications …, 2023 - nature.com
Cognitive impairment is a common symptom following mild traumatic brain injury (mTBI or
concussion) and can persist for years in some individuals. Hippocampal slice preparations …