Background Understanding gene function and genetic relationships is fundamental to our
efforts to better understand biological systems. Previous studies systematically describing …

The ability of injured axons to regenerate declines with age, yet the mechanisms that
regulate axon regeneration in response to age are not known. Here we show that axon …

Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a
neuronally expressed NAD + glycohydrolase whose activity is increased in response to stress. …

Neurons face a series of morphological and molecular changes following trauma and in the
progression of neurodegenerative disease. In neurons capable of mounting a spontaneous …

10.7554/eLife.12734.001 The ability of a neuron to regenerate its axon after injury depends
in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of …

This important study reveals a new role for TIR-1/SARM1 in inhibiting both axonal regeneration
and promoting axon degeneration in a novel axonal injury model. The authors provide …

How axons repair themselves after injury is a fundamental question in neurobiology. With its
conserved genome, relatively simple nervous system, and transparent body, C. elegans has …

Animals generate a wide range of highly coordinated motor outputs, which allows them to
execute purposeful behaviors. Individual neurons in the circuits that generate behaviors have …

Neurons communicate with other cells via axons and dendrites, slender membrane extensions
that contain pre- or post-synaptic specializations. If a neuron is damaged by injury or …

The postsynaptic membrane of the embryonic neuromuscular junction undergoes a dramatic
expansion during later development to facilitate the depolarization of larger muscles. In C. …