Association between schizophrenia and genetic variation in DCC: a case–control study
A Grant, F Fathalli, G Rouleau, R Joober… - Schizophrenia research, 2012 - Elsevier
Schizophrenia is a highly heritable neurodevelopmental disorder associated with alterations
in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance …
in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance …
Netrin‐1 receptor‐deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine
A Grant, D Hoops, C Labelle‐Dumais… - European Journal of …, 2007 - Wiley Online Library
The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …
[HTML][HTML] Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents
C Manitt, C Labelle-Dumais, C Eng, A Grant, A Mimee… - PloS one, 2010 - journals.plos.org
Puberty is a critical period in mesocorticolimbic dopamine (DA) system development,
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in early …
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in early …
[HTML][HTML] A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1
…, F Sarayloo, K Mourabit Amari, S Apuzzo, A Grant… - Scientific reports, 2018 - nature.com
Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution
remains poorly explained. In 2007, the first large scale genome wide association study (…
remains poorly explained. In 2007, the first large scale genome wide association study (…
[HTML][HTML] RNA-based therapy utilizing oculopharyngeal muscular dystrophy transcript knockdown and replacement
A Abu-Baker, N Kharma, J Perreault, A Grant… - … Therapy-Nucleic Acids, 2019 - cell.com
Oculopharyngeal muscular dystrophy (OPMD) is caused by a small expansion of a short
polyalanine (polyAla) tract in the poly(A)-binding protein nuclear 1 protein (PABPN1). Despite …
polyalanine (polyAla) tract in the poly(A)-binding protein nuclear 1 protein (PABPN1). Despite …
Post‐pubertal emergence of a dopamine phenotype in netrin‐1 receptor‐deficient mice
A Grant, Z Speed, C Labelle‐Dumais… - European Journal of …, 2009 - Wiley Online Library
During the pubertal period the mesocortical dopamine (DA) system undergoes substantial
reorganization of neuronal connectivity and functional refinement. Netrins are guidance cues …
reorganization of neuronal connectivity and functional refinement. Netrins are guidance cues …
Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan
M Pokinko, A Grant, F Shahabi, Y Dumont, C Manitt… - Neuroscience, 2017 - Elsevier
Adolescence is a period during which the medial prefrontal cortex (mPFC) undergoes
significant remodeling. The netrin-1 receptor, deleted in colorectal cancer (DCC), controls the …
significant remodeling. The netrin-1 receptor, deleted in colorectal cancer (DCC), controls the …
Assessing climate change impacts on the water quality of Scottish standing waters
…, LR Carvalho, P Hunter, M Corr, AJ Dobel, A Grant… - 2022 - nora.nerc.ac.uk
… Dobel, Alanna Grant, Gemma Nash, Emma Robinson and Bryan M. Spears (2022).
Assessing climate change impacts on the water quality of Scottish standing waters. …
Assessing climate change impacts on the water quality of Scottish standing waters. …
Mesocortical dopamine phenotypes in mice lacking the sonic hedgehog receptor Cdon
M Verwey, A Grant, N Meti, L Adye-White… - Eneuro, 2016 - eneuro.org
Motivated behaviors and many psychopathologies typically involve changes in dopamine
release from the projections of the ventral tegmental area (VTA) and/or the substantia nigra …
release from the projections of the ventral tegmental area (VTA) and/or the substantia nigra …
Haloperidol treatment downregulates DCC expression in the ventral tegmental area
A Grant, C Manitt, C Flores - Neuroscience letters, 2014 - Elsevier
A core feature in the pathophysiology of schizophrenia is abnormal development and function
of mesocorticolimbic dopamine (DA) circuitry. We have previously shown that variations in …
of mesocorticolimbic dopamine (DA) circuitry. We have previously shown that variations in …