Association between schizophrenia and genetic variation in DCC: a case–control study

A Grant, F Fathalli, G Rouleau, R Joober… - Schizophrenia research, 2012 - Elsevier
Schizophrenia is a highly heritable neurodevelopmental disorder associated with alterations
in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance …

Netrin‐1 receptor‐deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine

A Grant, D Hoops, C Labelle‐Dumais… - European Journal of …, 2007 - Wiley Online Library
The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …

[HTML][HTML] Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents

C Manitt, C Labelle-Dumais, C Eng, A Grant, A Mimee… - PloS one, 2010 - journals.plos.org
Puberty is a critical period in mesocorticolimbic dopamine (DA) system development,
particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in early …

[HTML][HTML] A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1

…, F Sarayloo, K Mourabit Amari, S Apuzzo, A Grant… - Scientific reports, 2018 - nature.com
Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution
remains poorly explained. In 2007, the first large scale genome wide association study (…

[HTML][HTML] RNA-based therapy utilizing oculopharyngeal muscular dystrophy transcript knockdown and replacement

A Abu-Baker, N Kharma, J Perreault, A Grant… - … Therapy-Nucleic Acids, 2019 - cell.com
Oculopharyngeal muscular dystrophy (OPMD) is caused by a small expansion of a short
polyalanine (polyAla) tract in the poly(A)-binding protein nuclear 1 protein (PABPN1). Despite …

Post‐pubertal emergence of a dopamine phenotype in netrin‐1 receptor‐deficient mice

A Grant, Z Speed, C Labelle‐Dumais… - European Journal of …, 2009 - Wiley Online Library
During the pubertal period the mesocortical dopamine (DA) system undergoes substantial
reorganization of neuronal connectivity and functional refinement. Netrins are guidance cues …

Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan

M Pokinko, A Grant, F Shahabi, Y Dumont, C Manitt… - Neuroscience, 2017 - Elsevier
Adolescence is a period during which the medial prefrontal cortex (mPFC) undergoes
significant remodeling. The netrin-1 receptor, deleted in colorectal cancer (DCC), controls the …

Assessing climate change impacts on the water quality of Scottish standing waters

…, LR Carvalho, P Hunter, M Corr, AJ Dobel, A Grant… - 2022 - nora.nerc.ac.uk
… Dobel, Alanna Grant, Gemma Nash, Emma Robinson and Bryan M. Spears (2022).
Assessing climate change impacts on the water quality of Scottish standing waters. …

Mesocortical dopamine phenotypes in mice lacking the sonic hedgehog receptor Cdon

M Verwey, A Grant, N Meti, L Adye-White… - Eneuro, 2016 - eneuro.org
Motivated behaviors and many psychopathologies typically involve changes in dopamine
release from the projections of the ventral tegmental area (VTA) and/or the substantia nigra …

Haloperidol treatment downregulates DCC expression in the ventral tegmental area

A Grant, C Manitt, C Flores - Neuroscience letters, 2014 - Elsevier
A core feature in the pathophysiology of schizophrenia is abnormal development and function
of mesocorticolimbic dopamine (DA) circuitry. We have previously shown that variations in …