10.7554/eLife.46323.001 Response inhibition is essential for navigating everyday life. Its
derailment is considered integral to numerous neurological and psychiatric disorders, and …

Physical exercise enhances a wide range of cognitive functions in humans. Running-induced
cognitive enhancement has also been demonstrated in rodents but with a strong emphasis …

Previous research has focused on the anterior cingulate cortex (ACC) as a key brain region
in the mitigation of the competition that arises from two simultaneously active signals. …

The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch
between two task-relevant dimensions. Changes in neuronal oscillations and alterations in …

Pillar[6]MaxQ (P6AS) functions as an in vivo sequestration agent for methamphetamine and
fentanyl. We use 1 H NMR, isothermal titration calorimetry, and molecular modeling to …

Opioid use by pregnant women is an understudied consequence associated with the opioid
epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS…

Autism spectrum disorder (ASD) is often associated with cognitive deficits and excessive
anxiety. Neuroimaging studies have shown atypical structure and neural connectivity in the …

Several human imaging studies have suggested that anterior cingulate cortex (ACC) is
highly active when participants receive competing inputs, and that these signals may be …

The ability to inhibit or adapt unwanted actions or movements is a critical feature of almost
all forms of behavior. Many have attributed this ability to frontal brain areas such as the …

We report investigations of the use of cucurbit[8]uril (CB[8]) macrocycles as an antidote to
counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB[8] …