The neurodegenerative diseases Huntington disease, dentatorubropallidoluysian atrophy,
spinocerebellar atrophy type 3, and spinal bulbar muscular atrophy are caused by expansion …

Huntington disease is an autosomal dominant neurodegenerative disorder caused by the
pathological expansion of a polyglutamine tract. In this study we directly assess the influence …

In Huntington disease, polyglutamine expansion of the protein huntingtin (Htt) leads to
selective neurodegenerative loss of medium spiny neurons throughout the striatum by an …

Purpose Retinoblastoma (RB) is the most common intraocular tumor of early childhood. The
early onset of RB, coupled with our previous findings of cancer stem cell characteristics in …

: X‐linked spinal and bulbar muscular atrophy (SBMA), Kennedy's disease, is a degenerative
disease of the motor neurons that is associated with an increase in the number of CAG …

The ketogenic diet (KD) is a high-fat low-carbohydrate diet that has been used for decades
as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric …

Wnt signaling regulates essential biological processes ranging from embryogenesis to
neurodegeneration. Recently, we demonstrated that Dickkopf3 (Dkk3) is a pro-survival …

The retina is a complex tissue composed of multiple interconnected cell layers, highly
specialized for transforming light and color into electrical signals perceived by the brain. Damage …

Brain-derived neurotrophic factor (BDNF) is a well characterized neurotrophin that mediates
a wide variety of activities in the central nervous system, including neuronal differentiation, …

The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays
critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone …