User profiles for A. D. Lam

Alice D. Lam

Massachusetts General Hospital
Verified email at mgh.harvard.edu
Cited by 1683

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

AD Lam, G Deck, A Goldman, EN Eskandar… - Nature medicine, 2017 - nature.com
… Interneurons, however, are among the first to die in AD … in cognition in individuals with
AD. Here we used intracranial … mTL activity in two patients with AD and fluctuating cognition. …

Association of epileptiform abnormalities and seizures in Alzheimer disease

AD Lam, RA Sarkis, KR Pellerin, J Jing, BA Dworetzky… - Neurology, 2020 - AAN Enterprises
… 13 A major barrier to progress is our limited understanding of biomarkers of hyperexcitability
in AD and their clinical relevance to AD pathophysiology and seizures. The best-known …

SNARE-catalyzed fusion events are regulated by Syntaxin1A–lipid interactions

AD Lam, P Tryoen-Toth, B Tsai, N Vitale… - Molecular biology of …, 2008 - Am Soc Cell Biol
Membrane fusion is a process that intimately involves both proteins and lipids. Although the
SNARE proteins, which ultimately overcome the energy barrier for fusion, have been …

Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth

…, CB Zhang, C Selli, G Tagliavini, AD Lam… - Journal of Experimental …, 2020 - rupress.org
Bone metastasis is the major cause of death in breast cancer. The lack of effective treatment
suggests that disease mechanisms are still largely unknown. As a key component of the …

[HTML][HTML] Macrophages promote anti-androgen resistance in prostate cancer bone disease

…, RY Ma, Y Lu, CB Zhang, B Xun, AD Lam… - Journal of Experimental …, 2023 - rupress.org
Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …

Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning

…, RA Sarkis, SS Cash, MB Westover, AD Lam - Sleep, 2020 - academic.oup.com
… ) probable Alzheimer’s disease, with no history of epilepsy (AD); (3) probable Alzheimer’s
disease with epilepsy related to Alzheimer’s (AD + Epilepsy); and (4) late-onset temporal lobe …

[HTML][HTML] Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells

ND Verma, AD Lam, C Chiu, GT Tran, BM Hall… - Scientific reports, 2021 - nature.com
Resting and activated subpopulations of CD4 + CD25 + CD127 lo T regulatory cells (Treg)
and CD4 + CD25 + CD127 + effector T cells in MS patients and in healthy individuals were …

Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning

…, KR Pellerin, MB Westover, SS Cash, AD Lam - Clinical …, 2020 - Elsevier
… Four-contact FO electrodes (Ad-Tech, Racine, WI) were placed bilaterally using fluoroscopic
… We use cookies to help provide and enhance our service and tailor content and ads. By …

Noninvasive detection of hippocampal epileptiform activity on scalp electroencephalogram

…, AJ Cole, SS Cash, MB Westover, AD Lam - JAMA …, 2022 - jamanetwork.com
… Dr Lam reported receiving grants from the National Institutes of Health, the American Academy
of Neurology Institute, and Sage Therapeutics; and personal fees from Sage Therapeutics…

Association of sleep electroencephalography-based brain age index with dementia

…, MJ Leone, L Paixao, RJ Thomas, AD Lam… - JAMA network …, 2020 - jamanetwork.com
… α/slow-wave power ratios in patients with AD. The increased θ/α ratio is also consistent with
… ratio was higher patients in AD compared with individuals without AD with the same age and …