User profiles for A. D. Lam
Alice D. LamMassachusetts General Hospital Verified email at mgh.harvard.edu Cited by 1683 |
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
AD Lam, G Deck, A Goldman, EN Eskandar… - Nature medicine, 2017 - nature.com
… Interneurons, however, are among the first to die in AD … in cognition in individuals with
AD. Here we used intracranial … mTL activity in two patients with AD and fluctuating cognition. …
AD. Here we used intracranial … mTL activity in two patients with AD and fluctuating cognition. …
Association of epileptiform abnormalities and seizures in Alzheimer disease
… 13 A major barrier to progress is our limited understanding of biomarkers of hyperexcitability
in AD and their clinical relevance to AD pathophysiology and seizures. The best-known …
in AD and their clinical relevance to AD pathophysiology and seizures. The best-known …
SNARE-catalyzed fusion events are regulated by Syntaxin1A–lipid interactions
Membrane fusion is a process that intimately involves both proteins and lipids. Although the
SNARE proteins, which ultimately overcome the energy barrier for fusion, have been …
SNARE proteins, which ultimately overcome the energy barrier for fusion, have been …
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth
…, CB Zhang, C Selli, G Tagliavini, AD Lam… - Journal of Experimental …, 2020 - rupress.org
Bone metastasis is the major cause of death in breast cancer. The lack of effective treatment
suggests that disease mechanisms are still largely unknown. As a key component of the …
suggests that disease mechanisms are still largely unknown. As a key component of the …
[HTML][HTML] Macrophages promote anti-androgen resistance in prostate cancer bone disease
…, RY Ma, Y Lu, CB Zhang, B Xun, AD Lam… - Journal of Experimental …, 2023 - rupress.org
Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …
Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning
… ) probable Alzheimer’s disease, with no history of epilepsy (AD); (3) probable Alzheimer’s
disease with epilepsy related to Alzheimer’s (AD + Epilepsy); and (4) late-onset temporal lobe …
disease with epilepsy related to Alzheimer’s (AD + Epilepsy); and (4) late-onset temporal lobe …
[HTML][HTML] Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells
Resting and activated subpopulations of CD4 + CD25 + CD127 lo T regulatory cells (Treg)
and CD4 + CD25 + CD127 + effector T cells in MS patients and in healthy individuals were …
and CD4 + CD25 + CD127 + effector T cells in MS patients and in healthy individuals were …
Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning
… Four-contact FO electrodes (Ad-Tech, Racine, WI) were placed bilaterally using fluoroscopic
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Noninvasive detection of hippocampal epileptiform activity on scalp electroencephalogram
… Dr Lam reported receiving grants from the National Institutes of Health, the American Academy
of Neurology Institute, and Sage Therapeutics; and personal fees from Sage Therapeutics…
of Neurology Institute, and Sage Therapeutics; and personal fees from Sage Therapeutics…
Association of sleep electroencephalography-based brain age index with dementia
… α/slow-wave power ratios in patients with AD. The increased θ/α ratio is also consistent with
… ratio was higher patients in AD compared with individuals without AD with the same age and …
… ratio was higher patients in AD compared with individuals without AD with the same age and …