Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
… A knock-in mouse line expressing Otx2-AA, which has a disrupted GAG-binding domain,
showed reduced specific accumulation of non-cell autonomous Otx2-AA protein in PV cells, …

[HTML][HTML] Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity

S Sugiyama, AA Di Nardo, S Aizawa, I Matsuo… - Cell, 2008 - cell.com
Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic
connections within visual cortex determine the timing of the critical period for rewiring ocular …

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR

…, X Salvatella, M Vendruscolo, AA Di Nardo… - Nature, 2004 - nature.com
Many biochemical processes proceed through the formation of functionally significant
intermediates 1 , 2 . Although the identification and characterization of such species can provide …

[PDF][PDF] Homeoprotein signaling in the developing and adult nervous system

A Prochiantz, AA Di Nardo - Neuron, 2015 - cell.com
Signaling classically involves the secretion of diverse molecules that bind specific cell-surface
receptors and engage intracellular transduction cascades. Some exceptions—namely, …

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex

…, S Sugiyama, C Bernard, AA Di Nardo… - Journal of …, 2012 - Soc Neuroscience
… We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2,
bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 …

The physiology of homeoprotein transduction

AA Di Nardo, J Fuchs, RL Joshi… - Physiological …, 2018 - journals.physiology.org
… In the Otx2-AA mouse model, the RK to AA mutation results in reduced affinity of mutated
Otx2(AA) protein for complex sugars within PV cell PNNs; Otx2(AA) protein now also …

[PDF][PDF] Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity

J Spatazza, HHC Lee, AA Di Nardo, L Tibaldi, A Joliot… - Cell reports, 2013 - cell.com
Brain plasticity is often restricted to critical periods in early life. Here, we show that a key
regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted …

Hydrophobic core packing in the SH3 domain folding transition state

JGB Northey, AA Di Nardo, AR Davidson - Nature structural biology, 2002 - nature.com
How tightly packed is the hydrophobic core of a folding transition state structure? We have
addressed this question by characterizing the effects on folding kinetics of >40 substitutions of …

Analysis of covariation in an SH3 domain sequence alignment: applications in tertiary contact prediction and the design of compensating hydrophobic core …

SM Larson, AA Di Nardo, AR Davidson - Journal of molecular biology, 2000 - Elsevier
We have analyzed sequence covariation in an alignment of 266 non-redundant SH3 domain
sequences using chi-squared statistical methods. Artifactual covariations arising from close …

Genetic Otx2 mis-localization delays critical period plasticity across brain regions

…, A Simeone, A Prochiantz, AA Di Nardo… - Molecular …, 2017 - nature.com
… , homozygous Otx2 AA/AA mice exhibit … Otx2 AA/AA mice, but not seen in heterozygous
Otx2 +/AA mice. As baseline visual acuity was similar between WT and heterozygous Otx2 +/AA