Long-term potentiation in the in vitro perirhinal cortex displays associative properties

D K Bilkey

doi:10.1016/0006-8993(96)00789-5

Long-term potentiation in the in vitro perirhinal cortex displays associative properties

Brain Res. 1996 Sep 16;733(2):297-300. doi: 10.1016/0006-8993(96)00789-5.

Author

D K Bilkey¹

Affiliation

¹ Department of Psychology, University of Otago, Dunedin, New Zealand. sycodkb@otago.ac.nz

PMID: 8891314
DOI: 10.1016/0006-8993(96)00789-5

Abstract

Brief high frequency tetanization trains reliably induced input-specific long-term potentiation (LTP) in slices of rat perirhinal cortex maintained in vitro. Furthermore, associative interactions between inputs were observed following simultaneous tetanization of separate inputs. This associativity may be mediated via NMDA receptors as LTP was blocked in the presence of APV. These results suggest that LTP may underline participation of perirhinal cortex in memory processes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Amino-5-phosphonovalerate / pharmacology*
Animals
Association Learning*
Brain Mapping*
Cerebral Cortex / drug effects
Cerebral Cortex / physiology*
Electric Stimulation
Limbic System / drug effects
Limbic System / physiology*
Long-Term Potentiation* / drug effects
Male
Memory / physiology*
Rats
Rats, Sprague-Dawley
Time Factors

Substances

2-Amino-5-phosphonovalerate