Abstract
An estimate of the prevalence of autism in tuberous sclerosis (TSC) was made by interviewing the parents of 21 children between ages 3 and 11 ascertained during a previous population study of the condition in the West of Scotland. Five of the children (24%) were rated autistic and a further four (19%), all of whom were girls, had socially impaired behavior categorized as pervasive developmental disorder, without fulfilling all the DSM-III-R criteria for autism. One further boy had disruptive attention-seeking behavior that had excluded him from his normal school. The estimated prevalence from this study of autism in TSC is 1 in 4 children in general, and 1 in 2 of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders, particularly in girls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Autistic Disorder / diagnosis
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Autistic Disorder / epidemiology*
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Autistic Disorder / genetics
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Child
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Child Development Disorders, Pervasive / diagnosis
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Child Development Disorders, Pervasive / epidemiology
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Child Development Disorders, Pervasive / genetics
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Child, Preschool
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Comorbidity
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Cross-Sectional Studies
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Female
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Humans
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Incidence
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Intellectual Disability / diagnosis
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Intellectual Disability / epidemiology
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Intellectual Disability / genetics
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Language Development Disorders / diagnosis
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Language Development Disorders / epidemiology
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Language Development Disorders / genetics
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Learning Disabilities / diagnosis
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Learning Disabilities / epidemiology
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Learning Disabilities / genetics
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Mainstreaming, Education
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Male
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / epidemiology*
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Neurocognitive Disorders / genetics
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Scotland / epidemiology
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Tuberous Sclerosis / diagnosis
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Tuberous Sclerosis / epidemiology*
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Tuberous Sclerosis / genetics