Abstract
In rats treated systemically with either amphetamine, amfonelic acid or apomorphine, large numbers of cells displaying Fos-like immunoreactivity (FLI) could be seen in the lateral zone of the lateral habenula. The induction of FLI by amphetamine could be blocked either by pretreatment with haloperidol or by 6-hydroxydopamine lesions of ascending dopamine fibers at the level of the lateral hypothalamus. In contrast, a variety of stressors selectively induced FLI in the most medial portion of the lateral habenula. These findings support the concept of a functional differentiation of the medial and lateral regions of the lateral habenula and provide further evidence for involvement of the habenula in the circuitry of the basal ganglia.
MeSH terms
-
Animals
-
Apomorphine / pharmacology
-
Dextroamphetamine / pharmacology
-
Dopamine / physiology*
-
Environment
-
Haloperidol / pharmacology
-
Immunohistochemistry
-
Lithium Chloride / pharmacology
-
Male
-
Nalidixic Acid / analogs & derivatives
-
Naphthyridines / pharmacology
-
Neostriatum / drug effects
-
Neostriatum / metabolism
-
Oncogene Proteins v-fos / immunology
-
Oncogene Proteins v-fos / metabolism*
-
Oxidopamine / pharmacology
-
Prosencephalon / drug effects
-
Prosencephalon / metabolism
-
Rats
-
Rats, Sprague-Dawley
-
Restraint, Physical
-
Stress, Psychological / metabolism*
-
Substantia Nigra / drug effects
-
Substantia Nigra / metabolism
-
Thalamus / drug effects
-
Thalamus / metabolism*
Substances
-
Naphthyridines
-
Oncogene Proteins v-fos
-
Nalidixic Acid
-
Oxidopamine
-
Lithium Chloride
-
Haloperidol
-
Apomorphine
-
amfonelic acid
-
Dextroamphetamine
-
Dopamine