Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

Annu Rev Cell Biol. 1994:10:373-403. doi: 10.1146/annurev.cb.10.110194.002105.
No abstract available

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Amyloid / metabolism
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / physiology*
  • Animals
  • Apolipoproteins E / genetics
  • Aspartic Acid Endopeptidases
  • Brain / pathology
  • Brain Chemistry
  • Cell Polarity
  • Endopeptidases / metabolism
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Nerve Tissue Proteins / metabolism
  • Neurofibrillary Tangles / pathology
  • Protein Processing, Post-Translational
  • Recombinant Proteins / metabolism

Substances

  • Amyloid
  • Amyloid beta-Protein Precursor
  • Apolipoproteins E
  • Nerve Tissue Proteins
  • Recombinant Proteins
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human