Abstract
Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified. Here, we discuss the nature of such GTPase-activating proteins (GAPs) and their potential importance for cell signalling.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Caenorhabditis elegans / metabolism
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Drosophila / metabolism
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GTP Phosphohydrolases / metabolism*
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GTP-Binding Proteins / metabolism*
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GTPase-Activating Proteins*
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Humans
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Mammals
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Saccharomyces cerevisiae / metabolism
Substances
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GTPase-Activating Proteins
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rho GTPase-activating protein
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GTP Phosphohydrolases
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GTP-Binding Proteins