minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

F Tejedor; X R Zhu; E Kaltenbach; A Ackermann; A Baumann; I Canal; M Heisenberg; K F Fischbach; O Pongs

doi:10.1016/0896-6273(95)90286-4

minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

Neuron. 1995 Feb;14(2):287-301. doi: 10.1016/0896-6273(95)90286-4.

Authors

F Tejedor¹, X R Zhu, E Kaltenbach, A Ackermann, A Baumann, I Canal, M Heisenberg, K F Fischbach, O Pongs

Affiliation

¹ Consejo Superior de Investigaciones Científicas, Instituto Cajal, Madrid, Spain.

PMID: 7857639
DOI: 10.1016/0896-6273(95)90286-4

Abstract

The development of the adult central nervous system of Drosophila requires a precise and reproducible pattern of neuroblast proliferation during postembryonic neurogenesis. We show here that mutations in the minibrain (mnb) gene cause an abnormal spacing of neuroblasts in the outer proliferation center (opc) of larval brain, with the implication that mnb opc neuroblasts produce less neuronal progeny than do wild type. As a consequence, the adult mnb brain exhibits a specific and marked size reduction of the optic lobes and central brain hemispheres. The insufficient number of distinct neurons in mnb brains is correlated with specific abnormalities in visual and olfactory behavior. The mnb gene encodes a novel, cell type-specific serine-threonine protein kinase family that is expressed and required in distinct neuroblast proliferation centers during postembryonic neurogenesis. The mnb kinases share extensive sequence similarities with kinases involved in the regulation of cell division.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
DNA Primers
DNA, Complementary
Drosophila Proteins*
Drosophila melanogaster / embryology
Drosophila melanogaster / physiology*
Dyrk Kinases
Embryo, Nonmammalian / enzymology
Embryo, Nonmammalian / physiology
Ganglia, Invertebrate / enzymology
Ganglia, Invertebrate / physiology
Gene Expression
Genes, Insect*
Humans
Mice
Molecular Sequence Data
Nervous System / embryology
Nervous System / enzymology*
Nervous System / growth & development
Polymerase Chain Reaction
Protein Kinases / biosynthesis*
Protein Serine-Threonine Kinases / biosynthesis*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Protein-Tyrosine Kinases
Restriction Mapping
Sequence Homology, Amino Acid

Substances

DNA Primers
DNA, Complementary
Drosophila Proteins
Protein Kinases
mnb protein, Drosophila
Protein-Tyrosine Kinases
Protein Serine-Threonine Kinases

Associated data

GENBANK/X70794