Abstract
We previously found two distinct types of responses to kainate in cultured rat hippocampal neurons. The type I response is characterized by very little increase in Ca2+ permeability with an outward rectification in the current-voltage (I-V) relation of the kainate response. In contrast, the type II kainate response is characterized by prominent Ca2+ permeability and an inward rectification. These two types of responses were mimicked by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA). Furthermore, AMPA cross-desensitized both types of kainate responses. These results indicate that two functionally different types of AMPA/kainate receptors are expressed in hippocampal neurons.
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / drug effects
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Calcium Channels / metabolism
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Cells, Cultured
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Hippocampus / cytology
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Hippocampus / drug effects*
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Ibotenic Acid / analogs & derivatives*
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Ibotenic Acid / pharmacology
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Ion Channel Gating / drug effects*
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Kainic Acid / pharmacology
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Membrane Potentials / drug effects
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Neurons / drug effects*
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Neurons / physiology
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Pyrrolidinones / pharmacology
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Rats
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Receptors, AMPA
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Receptors, Glutamate / drug effects*
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Receptors, Glutamate / physiology
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Receptors, Kainic Acid
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Substances
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Calcium Channels
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Pyrrolidinones
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Receptors, AMPA
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Receptors, Glutamate
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Receptors, Kainic Acid
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Ibotenic Acid
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aniracetam
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Kainic Acid
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Calcium