Two distinct types of AMPA responses in cultured rat hippocampal neurons

Neurosci Lett. 1993 Jun 11;155(2):187-90. doi: 10.1016/0304-3940(93)90704-o.

Abstract

We previously found two distinct types of responses to kainate in cultured rat hippocampal neurons. The type I response is characterized by very little increase in Ca2+ permeability with an outward rectification in the current-voltage (I-V) relation of the kainate response. In contrast, the type II kainate response is characterized by prominent Ca2+ permeability and an inward rectification. These two types of responses were mimicked by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA). Furthermore, AMPA cross-desensitized both types of kainate responses. These results indicate that two functionally different types of AMPA/kainate receptors are expressed in hippocampal neurons.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / drug effects
  • Calcium Channels / metabolism
  • Cells, Cultured
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Ibotenic Acid / analogs & derivatives*
  • Ibotenic Acid / pharmacology
  • Ion Channel Gating / drug effects*
  • Kainic Acid / pharmacology
  • Membrane Potentials / drug effects
  • Neurons / drug effects*
  • Neurons / physiology
  • Pyrrolidinones / pharmacology
  • Rats
  • Receptors, AMPA
  • Receptors, Glutamate / drug effects*
  • Receptors, Glutamate / physiology
  • Receptors, Kainic Acid
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Substances

  • Calcium Channels
  • Pyrrolidinones
  • Receptors, AMPA
  • Receptors, Glutamate
  • Receptors, Kainic Acid
  • Ibotenic Acid
  • aniracetam
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
  • Kainic Acid
  • Calcium