Voltage imaging in the olfactory bulb using transgenic mouse lines expressing the genetically encoded voltage indicator ArcLight

Sci Rep. 2022 Feb 3;12(1):1875. doi: 10.1038/s41598-021-04482-3.

Abstract

Genetically encoded voltage indicators (GEVIs) allow optical recordings of membrane potential changes in defined cell populations. Transgenic reporter animals that facilitate precise and repeatable targeting with high expression levels would further the use of GEVIs in the in vivo mammalian brain. However, the literature on developing and applying transgenic mouse lines as vehicles for GEVI expression is limited. Here we report the first in vivo experiments using a transgenic reporter mouse for the GEVI ArcLight, which utilizes a Cre/tTA dependent expression system (TIGRE 1.0). We developed two mouse lines with ArcLight expression restricted to either olfactory receptor neurons, or a subpopulation of interneurons located in the granule and glomerular layers in the olfactory bulb. The ArcLight expression in these lines was sufficient for in vivo imaging of odorant responses in single trials using epifluorescence and 2-photon imaging. The voltage responses were odor-specific and concentration-dependent, which supported earlier studies about perceptual transformations carried out by the bulb that used calcium sensors of neural activity. This study demonstrates that the ArcLight transgenic line is a flexible genetic tool that can be used to record the neuronal electrical activity of different cell types with a signal-to-noise ratio that is comparable to previous reports using viral transduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biosensing Techniques*
  • Genes, Reporter
  • Interneurons / metabolism*
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism*
  • Membrane Potentials*
  • Mice, Transgenic
  • Microscopy, Fluorescence, Multiphoton
  • Odorants
  • Olfactory Bulb / cytology
  • Olfactory Bulb / metabolism*
  • Olfactory Perception
  • Olfactory Receptor Neurons / metabolism*
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism*
  • Smell
  • Voltage-Sensitive Dye Imaging*

Substances

  • Arclight fusion protein
  • Luminescent Proteins
  • Recombinant Fusion Proteins