Abstract
Depletion of catecholamines by pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine attenuated the ability of the selective D-2 dopamine receptor agonist quinpirole to inhibit rat nucleus accumbens neurons when applied directly by microiontophoresis. Concurrent iontophoretic administration of the D-1 selective agonist SKF 38393, at currents which alone produced little inhibition, reinstated the inhibitory effect of quinpirole. These findings suggest that D-1 receptor stimulation may play a necessary 'enabling' role for D-2 receptor-mediated functional responses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Animals
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Appetite Depressants / pharmacology
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Benzazepines / pharmacology
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Ergolines / pharmacology
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Male
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Neurons / metabolism*
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism*
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Quinpirole
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / metabolism*
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Septal Nuclei / metabolism*
Substances
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Appetite Depressants
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Benzazepines
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Ergolines
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Receptors, Dopamine
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Quinpirole
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine