TET enzymes in neurophysiology and brain function

Neurosci Biobehav Rev. 2019 Jul:102:337-344. doi: 10.1016/j.neubiorev.2019.05.006. Epub 2019 May 9.

Abstract

The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.

Keywords: 5hmC; Behavior; Epigenetics; Neuronal plasticity; TET enzymes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 5-Methylcytosine / analogs & derivatives*
  • 5-Methylcytosine / physiology
  • Animals
  • Brain / enzymology
  • Brain / physiology*
  • DNA Methylation / physiology*
  • Dioxygenases / physiology*
  • Epigenesis, Genetic / physiology*
  • Humans
  • Mixed Function Oxygenases / physiology*
  • Neuronal Plasticity / physiology*

Substances

  • 5-hydroxymethylcytosine
  • 5-Methylcytosine
  • Mixed Function Oxygenases
  • Dioxygenases