Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

A M Davies; C Bandtlow; R Heumann; S Korsching; H Rohrer; H Thoenen

doi:10.1038/326353a0

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

Nature. 1987;326(6111):353-8. doi: 10.1038/326353a0.

Authors

A M Davies, C Bandtlow, R Heumann, S Korsching, H Rohrer, H Thoenen

PMID: 3031505
DOI: 10.1038/326353a0

Abstract

We show that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until their fibres reach their cutaneous targets. Both cutaneous epithelium and mesenchyme synthesize NGF, the concentration of messenger RNA for NGF being higher in the more densely innervated epithelium.

MeSH terms

Animals
Epithelium / metabolism
Mesoderm / metabolism
Mice
Nerve Fibers / metabolism
Nerve Growth Factors / biosynthesis*
Neurons, Afferent / metabolism
Nucleic Acid Hybridization
RNA, Messenger / metabolism
Receptors, Cell Surface / metabolism*
Receptors, Nerve Growth Factor
Skin / embryology
Skin / innervation*

Substances

Nerve Growth Factors
RNA, Messenger
Receptors, Cell Surface
Receptors, Nerve Growth Factor