Abstract
The intra-arterial administration of vasoactive intestinal polypeptide (VIP, 1-10 micrograms, i.a.) to the cat superior cervical ganglion facilitated or unmasked the late component but not the early component of the 5-hydroxytryptamine (5-HT, 0.5-50 micrograms, i.a.)-induced postganglionic discharge. The facilitation occurred in acutely and chronically decentralized ganglia. The early and late 5-HT discharges were blocked by MDL-72222, a 5-HT antagonist, but not by cholinergic antagonists. These data together with previous observations indicate that VIP selectively facilitates slow cholinergic and non-cholinergic excitatory mechanisms in autonomic ganglia.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Atropine / pharmacology
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Autonomic Fibers, Postganglionic / drug effects
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Autonomic Fibers, Postganglionic / physiology*
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Cats
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Female
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Ganglia, Sympathetic / drug effects
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Ganglia, Sympathetic / physiology*
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Hexamethonium
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Hexamethonium Compounds / pharmacology
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Male
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Membrane Potentials / drug effects
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Serotonin / physiology*
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Serotonin Antagonists / pharmacology
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Tropanes / pharmacology
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Vasoactive Intestinal Peptide / physiology*
Substances
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Hexamethonium Compounds
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Serotonin Antagonists
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Tropanes
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Serotonin
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Vasoactive Intestinal Peptide
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Hexamethonium
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Atropine
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bemesetron