Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

Tristan Shuman; Benjamin Amendolara; Peyman Golshani

doi:10.5698/1535-7511.17.2.107

Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

Epilepsy Curr. 2017 Mar-Apr;17(2):107-111. doi: 10.5698/1535-7511.17.2.107.

Authors

Tristan Shuman¹, Benjamin Amendolara^{1

2

3}, Peyman Golshani^{1

4

5

6}

Affiliations

¹ Departments of Neurology and Psychiatry, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.
² UCLA Medical Scientist Training Program, Los Angeles, CA.
³ Neuroscience Interdepartmental Program, UCLA, Los Angeles, CA.
⁴ West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA.
⁵ Intellectual and Developmental Disability Research Center, UCLA, Los Angeles, CA.
⁶ Integrative Center for Learning and Memory, UCLA, Los Angeles, CA.

Abstract

Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.