And Akt-ion! IQGAP1 in control of signaling pathways

ERK signaling and Akt signaling are inversely correlated in some cancers. Yet, the precise molecular mechanism for cross‐inhibition remains unclear. In this issue of The EMBO Journal, Pan et al (2017) show that when Akt is on, its phosphorylated cytoplasmic substrate FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold IQGAP1.