Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation

Transl Psychiatry. 2016 Aug 23;6(8):e873. doi: 10.1038/tp.2016.153.

Abstract

Posttraumatic stress disorder is characterized by hyperarousal, sensory processing impairments, sleep disturbances and altered fear regulation; phenotypes associated with changes in brain oscillatory activity. Molecules associated with activity-dependent plasticity, including brain-derived neurotrophic factor (BDNF), may regulate neural oscillations by controlling synaptic activity. BDNF synthesis includes production of multiple Bdnf transcripts, which contain distinct 5' noncoding exons. We assessed arousal, sensory processing, fear regulation and sleep in animals where BDNF expression from activity-dependent promoter IV is disrupted (Bdnf-e4 mice). Bdnf-e4 mice display sensory hyper-reactivity and impaired electrophysiological correlates of sensory information processing as measured by event-related potentials (ERP). Utilizing electroencephalogram, we identified a decrease in slow-wave activity during non-rapid eye movement sleep, suggesting impaired sleep homeostasis. Fear extinction is controlled by hippocampal-prefrontal cortical BDNF signaling, and neurophysiological communication patterns between the hippocampus (HPC) and medial prefrontal cortex (mPFC) correlate with behavioral performance during extinction. Impaired fear extinction in Bdnf-e4 mice is accompanied by increased HPC activation and decreased HPC-mPFC theta phase synchrony during early extinction, as well as increased mPFC activation during extinction recall. These results suggest that activity-dependent BDNF signaling is critical for regulating oscillatory activity, which may contribute to altered behavior.

MeSH terms

  • Animals
  • Arousal / genetics*
  • Arousal / physiology
  • Brain Waves / genetics*
  • Brain Waves / physiology
  • Brain-Derived Neurotrophic Factor / genetics*
  • Brain-Derived Neurotrophic Factor / metabolism
  • Electroencephalography
  • Evoked Potentials / genetics*
  • Evoked Potentials / physiology
  • Extinction, Psychological / physiology
  • Fear / physiology
  • Hippocampus / physiopathology
  • Mice
  • Prefrontal Cortex / physiopathology
  • Prepulse Inhibition
  • Promoter Regions, Genetic
  • Reflex, Startle
  • Sleep / genetics*
  • Sleep / physiology
  • Stress Disorders, Post-Traumatic / genetics*
  • Stress Disorders, Post-Traumatic / physiopathology
  • Theta Rhythm / genetics
  • Theta Rhythm / physiology

Substances

  • Brain-Derived Neurotrophic Factor