BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images

Hanchuan Peng; Michael Hawrylycz; Jane Roskams; Sean Hill; Nelson Spruston; Erik Meijering; Giorgio A Ascoli

doi:10.1016/j.neuron.2015.06.036

BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images

Neuron. 2015 Jul 15;87(2):252-6. doi: 10.1016/j.neuron.2015.06.036.

Authors

Hanchuan Peng¹, Michael Hawrylycz², Jane Roskams³, Sean Hill⁴, Nelson Spruston⁵, Erik Meijering⁶, Giorgio A Ascoli⁷

Affiliations

¹ Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: hanchuanp@alleninstitute.org.
² Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: mikeh@alleninstitute.org.
³ Allen Institute for Brain Science, Seattle, WA 98103, USA.
⁴ Center for Brain Simulation, Campus Biotech, Chemin des Mines, 9, 1202 Geneva, Switzerland.
⁵ Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
⁶ Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, the Netherlands.
⁷ Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA. Electronic address: ascoli@gmu.edu.

Abstract

Understanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated reconstruction of dendritic and axonal morphology of single neurons.

MeSH terms

Algorithms
Animals
Computational Biology
Humans
Imaging, Three-Dimensional*
Microscopy / methods*
Models, Neurological*
Neurons / cytology*
Optical Imaging

Abstract

MeSH terms

Grants and funding