Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder

Hear Res. 2015 Dec;330(Pt B):213-20. doi: 10.1016/j.heares.2015.06.014. Epub 2015 Jun 25.

Abstract

The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).

Keywords: Auditory brainstem responses; Auditory processing disorder; First spike latency; Jitter; Kv1.1; Quivering; βIV-spectrin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Pathways / physiopathology*
  • Auditory Perception*
  • Auditory Perceptual Disorders / genetics
  • Auditory Perceptual Disorders / physiopathology*
  • Auditory Perceptual Disorders / psychology
  • Disease Models, Animal
  • Evoked Potentials, Auditory, Brain Stem
  • Genetic Predisposition to Disease
  • Hearing*
  • Humans
  • Mice
  • Mutation
  • Nerve Tissue Proteins / genetics
  • Phenotype
  • Reaction Time
  • Speech Perception
  • Synaptic Transmission*
  • Time Factors

Substances

  • Nerve Tissue Proteins