Brain rhythms connect impaired inhibition to altered cognition in schizophrenia

Biol Psychiatry. 2015 Jun 15;77(12):1020-30. doi: 10.1016/j.biopsych.2015.02.005. Epub 2015 Feb 14.

Abstract

In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillations in neuronal activity tie the pathophysiology of schizophrenia to alterations in local processing and large-scale coordination, and these alterations in turn can lead to the cognitive and perceptual disturbances observed in schizophrenia.

Keywords: Brain rhythms; Cognition; Functional connectivity; Inhibitory interneurons; Schizophrenia; Temporal coding.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology*
  • Brain Waves / physiology*
  • GABAergic Neurons / physiology
  • Genetic Predisposition to Disease
  • Humans
  • Interneurons / physiology
  • Neural Inhibition*
  • Schizophrenia / genetics
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*