Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans

J Neurophysiol. 2015 Nov;114(5):2551-4. doi: 10.1152/jn.00948.2014. Epub 2015 Feb 18.

Abstract

Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their findings stress that atypical activity in the efferent auditory pathway may represent a shared substrate, as well as a potential therapeutic target, in tinnitus and hyperacusis.

Keywords: efferent; hyperacusis; medial olivocochlear; tinnitus.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Auditory Pathways
  • Cochlea
  • Efferent Pathways
  • Humans
  • Hyperacusis*
  • Tinnitus*