Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: New endoplasmic reticulum stress response proteins

Hao Liu; Xiaolei Tang; Lei Gong

doi:10.1016/j.ejphar.2015.01.016

Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: New endoplasmic reticulum stress response proteins

Eur J Pharmacol. 2015 Mar 5:750:118-22. doi: 10.1016/j.ejphar.2015.01.016. Epub 2015 Jan 28.

Authors

Hao Liu¹, Xiaolei Tang², Lei Gong³

Affiliations

¹ Yuhuangding Hospital, Yantai, Shandong Province, PR China.
² Taishan Medical College, Taian, Shandong Province, PR China.
³ Yuhuangding Hospital, Yantai, Shandong Province, PR China. Electronic address: leigong27@163.com.

PMID: 25637781
DOI: 10.1016/j.ejphar.2015.01.016

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) are a novel evolutionary conserved neurotrophic factor (NTF) family. There are two distinct domains in MANF and CDNF 3-dimentional structure, N-terminal saposin-like domain and C-terminal SAP-domain, which suggest their unique mode of action. Although identified for their neurotrophic activity, recent studies have shown MANF and CDNF can protect cells during endoplasmic reticulum (ER) stress. This review summarizes the unique structure and related potential protective role for cells during ER stress of MANF and CDNF.

Keywords: CDNF; ER stress; MANF; NTF.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
Endoplasmic Reticulum Stress*
Gene Expression Regulation
Humans
Molecular Sequence Data
Nerve Growth Factors / chemistry
Nerve Growth Factors / metabolism*
Protein Structure, Tertiary

Substances

Nerve Growth Factors