Potentiation of 17β-estradiol on neuroexcitability by HCN-mediated neuromodulation of fast-afterhyperpolarization and late-afterdepolarization in low-threshold and sex-specific myelinated Ah-type baroreceptor neurons via GPR30 in female rats

Jian-Li He; Jun-Nan Li; Chun-Mei Zuo; Lu-Qi Wang; Xin Wen; Meng Zuo; Jian Guan; Di Wu; Dong-Xue Song; Xue Yu; Mei-Yu Qu; Yang Liu; Guo-Fen Qiao; Bai-Yan Li

doi:10.1016/j.ijcard.2014.12.068

Potentiation of 17β-estradiol on neuroexcitability by HCN-mediated neuromodulation of fast-afterhyperpolarization and late-afterdepolarization in low-threshold and sex-specific myelinated Ah-type baroreceptor neurons via GPR30 in female rats

Int J Cardiol. 2015 Mar 1:182:174-8. doi: 10.1016/j.ijcard.2014.12.068. Epub 2014 Dec 24.

Authors

Jian-Li He¹, Jun-Nan Li¹, Chun-Mei Zuo², Lu-Qi Wang³, Xin Wen¹, Meng Zuo¹, Jian Guan¹, Di Wu³, Dong-Xue Song¹, Xue Yu³, Mei-Yu Qu³, Yang Liu¹, Guo-Fen Qiao⁴, Bai-Yan Li⁵

Affiliations

¹ Department of Pharmacology, Harbin Medical University, Harbin, China.
² Department of Gynecology and Obstetrics, 211 Hospital of People's Liberation Army, Harbin, China.
³ Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin China.
⁴ Department of Pharmacology, Harbin Medical University, Harbin, China; Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin China.
⁵ Department of Pharmacology, Harbin Medical University, Harbin, China. Electronic address: BYL3176033110@163.com.

PMID: 25577757
DOI: 10.1016/j.ijcard.2014.12.068

No abstract available

Keywords: 17β-estradiol; Baroreceptor neuron; Fast afterhyperpolarization; Hyperpolarization-activated current; Late afterdepolarization; Potentiation.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials / drug effects
Animals
Baroreflex / drug effects
Baroreflex / physiology*
Disease Models, Animal
Estradiol / pharmacology*
Estrogens / pharmacology
Female
Nerve Fibers, Myelinated / drug effects*
Neurons, Afferent / drug effects*
Neurons, Afferent / metabolism
Ovariectomy
Pressoreceptors / drug effects*
Pressoreceptors / metabolism
Pressoreceptors / physiopathology
Rats
Receptors, G-Protein-Coupled / metabolism*

Substances

Estrogens
Gper1 protein, rat
Receptors, G-Protein-Coupled
Estradiol