Abstract
This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Brain Ischemia / complications
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Brain Ischemia / immunology*
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Brain Ischemia / pathology
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Humans
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Neurodegenerative Diseases / etiology
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Neurodegenerative Diseases / immunology*
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Neurodegenerative Diseases / pathology
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Spleen / immunology*
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Spleen / pathology
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Stroke / complications
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Stroke / immunology*
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Stroke / pathology