Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms

Eve Marder; Marie L Goeritz; Adriane G Otopalik

doi:10.1016/j.conb.2014.10.012

Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms

Curr Opin Neurobiol. 2015 Apr:31:156-63. doi: 10.1016/j.conb.2014.10.012. Epub 2014 Nov 6.

Authors

Eve Marder¹, Marie L Goeritz², Adriane G Otopalik²

Affiliations

¹ Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States. Electronic address: marder@brandeis.edu.
² Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States.

Abstract

Small central pattern generating circuits found in invertebrates have significant advantages for the study of the circuit mechanisms that generate brain rhythms. Experimental and computational studies of small oscillatory circuits reveal that similar rhythms can arise from disparate mechanisms. Animal-to-animal variation in the properties of single neurons and synapses may underly robust circuit performance, and can be revealed by perturbations. Neuromodulation can produce altered circuit performance but also ensure reliable circuit function.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Action Potentials / physiology*
Animals
Brain / cytology
Brain / physiology*
Central Pattern Generators / physiology*
Computer Simulation
Models, Neurological*

Abstract

Publication types

MeSH terms

Grants and funding