Beyond the connectome: the dynome

Nancy J Kopell; Howard J Gritton; Miles A Whittington; Mark A Kramer

doi:10.1016/j.neuron.2014.08.016

Beyond the connectome: the dynome

Neuron. 2014 Sep 17;83(6):1319-28. doi: 10.1016/j.neuron.2014.08.016.

Authors

Nancy J Kopell¹, Howard J Gritton², Miles A Whittington³, Mark A Kramer⁴

Affiliations

¹ Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA. Electronic address: nk@math.bu.edu.
² Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
³ The Hull York Medical School, University of York, Heslington, York YO10 5DD, UK.
⁴ Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.

Abstract

The human connectome will provide a detailed mapping of the brain's connectivity, with fundamental insights for health and disease. However, further understanding of brain function and dysfunction will require an integrated framework that links brain connectivity with brain dynamics, as well as the biological details that relate this connectivity more directly to function. In this Perspective, we describe such a framework for studying the brain's "dynome" and its relationship to cognition.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Brain / anatomy & histology*
Brain / physiology*
Connectome / methods*
Humans
Models, Neurological*

Abstract

Publication types

MeSH terms

Grants and funding