Impairments in goal-directed actions predict treatment response to cognitive-behavioral therapy in social anxiety disorder

PLoS One. 2014 Apr 11;9(4):e94778. doi: 10.1371/journal.pone.0094778. eCollection 2014.

Abstract

Social anxiety disorder is characterized by excessive fear and habitual avoidance of social situations. Decision-making models suggest that patients with anxiety disorders may fail to exhibit goal-directed control over actions. We therefore investigated whether such biases may also be associated with social anxiety and to examine the relationship between such behavior with outcomes from cognitive-behavioral therapy. Patients diagnosed with social anxiety and controls completed an instrumental learning task in which two actions were performed to earn food outcomes. After outcome devaluation, where one outcome was consumed to satiety, participants were re-tested in extinction. Results indicated that, as expected, controls were goal-directed, selectively reducing responding on the action that previously delivered the devalued outcome. Patients with social anxiety, however, exhibited no difference in responding on either action. This loss of a devaluation effect was associated with greater symptom severity and poorer response to therapy. These findings indicate that variations in goal-directed control in social anxiety may represent both a behavioral endophenotype and may be used to predict individuals who will respond to learning-based therapies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / therapy*
  • Cognitive Behavioral Therapy*
  • Female
  • Humans
  • Male
  • Prognosis
  • Treatment Outcome
  • Young Adult

Grants and funding

This study was supported by a Linkage Grant to A. J. Guastella (571101) and a Laureate Fellowship (FL0992409) to B. W. Balleine, both from the Australian Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.