Abstract
The capsaicin-sensitive afferent innervation of the urinary bladder and the central nervous system distribution of urinary bladder afferents have been studied in the rat. Capsaicin-sensitive primary sensory neurones supplying the urinary bladder have been found in two groups of spinal ganglia located in the Th13-L2 and L6-S1 segments. Capsaicin-sensitive primary sensory afferents from the bladder terminate within Rexed's laminae I, V and X, and in the dorsal gray commissure of the lumbosacral spinal cord. In addition, the results point to a possible vagal sensory innervation of the urinary bladder.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Afferent Pathways / anatomy & histology
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Afferent Pathways / cytology
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Animals
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Capsaicin / pharmacology*
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Ganglia, Spinal / anatomy & histology
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Ganglia, Spinal / cytology
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Horseradish Peroxidase
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Male
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Nerve Degeneration / drug effects
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Neurons, Afferent / classification
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Neurons, Afferent / cytology*
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Neurons, Afferent / drug effects
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Rats
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Rats, Inbred Strains
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Spinal Cord / anatomy & histology*
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Spinal Cord / cytology
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Urinary Bladder / innervation*
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Wheat Germ Agglutinins
Substances
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Wheat Germ Agglutinins
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Horseradish Peroxidase
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Capsaicin