Abstract
Solitary chemosensory cells in the non-neuronal epithelium of the anterior nasal cavity have bitter taste cell-like molecular characteristics and are involved in the detection of noxious substances. Here, we demonstrate that Pou2f3/Skn-1a, which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation*
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Epithelial Cells / cytology*
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Epithelial Cells / metabolism
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Gene Knockout Techniques
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Mice
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Nasal Cavity / cytology*
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Octamer Transcription Factors / deficiency
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Octamer Transcription Factors / genetics
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Octamer Transcription Factors / metabolism*
Substances
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Octamer Transcription Factors
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Pou2f3 protein, mouse