Abstract
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acoustic Stimulation
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Action Potentials / physiology
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Afferent Pathways / physiology*
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Animals
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Auditory Cortex / cytology*
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Auditory Cortex / physiology*
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Channelrhodopsins
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Dependovirus / genetics
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Female
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Green Fluorescent Proteins / genetics
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Mice
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Optogenetics
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Parvalbumins / genetics
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Parvalbumins / metabolism
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Patch-Clamp Techniques
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Photic Stimulation
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Reaction Time
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Sensory Receptor Cells / physiology*
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Statistics, Nonparametric
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Transduction, Genetic
Substances
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Channelrhodopsins
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Parvalbumins
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enhanced green fluorescent protein
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Green Fluorescent Proteins