Abstract
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Publication types
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Research Support, Non-U.S. Gov't
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Video-Audio Media
MeSH terms
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Adenosine Triphosphate / pharmacology
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Animals
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Brain / cytology
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Calcium / metabolism
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Cerebral Ventricles / anatomy & histology*
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Cerebral Ventricles / drug effects
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Cerebrospinal Fluid / drug effects
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Cerebrospinal Fluid / metabolism
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Cilia / drug effects
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Cilia / physiology*
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Electric Stimulation
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Ependyma / anatomy & histology*
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Female
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Hormone Antagonists / pharmacology
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Hypothalamic Hormones / deficiency
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Hypothalamic Hormones / pharmacology*
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In Vitro Techniques
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Male
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Melanins / deficiency
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Melanins / pharmacology*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Nerve Tissue Proteins / metabolism
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Neurons / drug effects
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Neurons / metabolism
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Pituitary Hormones / deficiency
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Pituitary Hormones / pharmacology*
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Receptors, Somatostatin / deficiency
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Receptors, Somatostatin / genetics
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Serotonin / pharmacology
Substances
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Hormone Antagonists
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Hypothalamic Hormones
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Mchr1 protein, mouse
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Melanins
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Nerve Tissue Proteins
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Pituitary Hormones
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Receptors, Somatostatin
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Serotonin
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melanin-concentrating hormone
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Adenosine Triphosphate
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Calcium