Abstract
The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Action Potentials / genetics
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Action Potentials / physiology
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Animals
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CA1 Region, Hippocampal / cytology
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CA1 Region, Hippocampal / physiology*
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Cell Shape / genetics
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Cell Shape / physiology
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Excitatory Postsynaptic Potentials / genetics
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Excitatory Postsynaptic Potentials / physiology*
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Glutamic Acid / physiology*
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Mice
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Patch-Clamp Techniques
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Pyramidal Cells / cytology
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Pyramidal Cells / physiology*
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Synapses / genetics
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Synapses / physiology*
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Synaptic Transmission / genetics
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Synaptic Transmission / physiology*
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gamma-Aminobutyric Acid / physiology
Substances
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Glutamic Acid
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gamma-Aminobutyric Acid