Abstract
Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Action Potentials / physiology
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Animals
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Dendrites / ultrastructure*
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Down-Regulation / drug effects*
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Down-Regulation / physiology
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Ethanol / administration & dosage
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Ethanol / pharmacology*
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Extinction, Psychological / drug effects*
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Extinction, Psychological / physiology
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Fear / physiology
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Mice
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Neurons / physiology
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Prefrontal Cortex / drug effects*
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Prefrontal Cortex / physiology
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / physiology*
Substances
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Receptors, N-Methyl-D-Aspartate
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Ethanol