Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons

M A Bisby; S Chen

doi:10.1016/0006-8993(90)90666-y

Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons

Brain Res. 1990 Oct 15;530(1):117-20. doi: 10.1016/0006-8993(90)90666-y.

Authors

M A Bisby¹, S Chen

Affiliation

¹ Department of Physiology, Queen's University, Kingston, Ontario, Canada.

PMID: 2271939
DOI: 10.1016/0006-8993(90)90666-y

Abstract

Wallerian degeneration is delayed following sciatic nerve crush in C57BL/Ola mice. Compared to C57BL/6J mice, regeneration of sensory axons is significantly slowed in the Ola mice, but reinnervation does eventually occur. We conclude that Wallerian degeneration is a prerequisite for normal sensory axon regeneration following a crush injury to peripheral nerve.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Axons / physiology*
Mice
Mice, Inbred C57BL
Nerve Crush
Nerve Regeneration / physiology*
Neurons, Afferent / physiology*
Sciatic Nerve / physiology*
Species Specificity
Wallerian Degeneration / physiology*