Abstract
Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Aged
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Analysis of Variance
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Brain / blood supply*
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Brain / drug effects*
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Brain Injuries / complications
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Brain Injuries / drug therapy
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Brain Mapping
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Bromocriptine / therapeutic use*
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Cross-Over Studies
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Dopamine Agonists / therapeutic use*
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Double-Blind Method
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Female
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Humans
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Image Processing, Computer-Assisted
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Magnetic Resonance Imaging / methods
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Male
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Memory Disorders / blood
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Memory Disorders / drug therapy*
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Memory Disorders / etiology
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Memory, Short-Term / drug effects*
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Middle Aged
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Neuropsychological Tests
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Oxygen / blood
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Prolactin / blood
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Young Adult
Substances
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Dopamine Agonists
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Bromocriptine
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Prolactin
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Oxygen