Abstract
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aging / metabolism
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Animals
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Behavior, Animal
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Embryo, Mammalian / metabolism
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Gene Dosage / genetics
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Genetic Techniques*
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Hyperalgesia / pathology
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Hyperalgesia / physiopathology
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Integrases / metabolism*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Microfilament Proteins / metabolism*
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Nociception / physiology
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Sensory Receptor Cells / metabolism
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Staining and Labeling
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beta-Galactosidase / metabolism
Substances
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Avil protein, mouse
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Microfilament Proteins
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Cre recombinase
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Integrases
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beta-Galactosidase