Abstract
Calcium ion entry through voltage-gated calcium channels is essential for cellular signalling in a wide variety of cells and multiple physiological processes. Perturbations of voltage-gated calcium channel function can lead to pathophysiological consequences. Calcium binding proteins serve as calcium sensors and regulate the calcium channel properties via feedback mechanisms. This review highlights the current evidences of calcium binding protein-mediated channel regulation in human diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium Channels, L-Type / genetics
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Calcium Channels, L-Type / metabolism*
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism
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Calcium-Binding Proteins / physiology*
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Disease / etiology*
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Disease / genetics
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Humans
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Ion Channel Gating / physiology
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Macular Degeneration / etiology
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Macular Degeneration / genetics
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Macular Degeneration / metabolism
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Migraine with Aura / etiology
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Migraine with Aura / genetics
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Migraine with Aura / metabolism
Substances
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Calcium Channels, L-Type
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Calcium-Binding Proteins